Venofer (iron sucrose) dose calculator | Calculosaurus.com Venofer Dosing and Administration A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. 2010;18(3). Use Caution/Monitor. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . *Repeat dose if iron deficiency anemia reoccurs. Applies only to oral form of both agents. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. Applies only to oral form of both agents. iron sucrose decreases levels of deferiprone by enhancing GI absorption. PDF GUIDELINES FOR IRON INFUSION USE IN ADULTS - Brockville General Hospital May increase risk of hypotension. This website is intended for use by US healthcare professionals only. Calculosaurus | Ferinject dose calculator iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Calculation of the Total Iron Deficit - Alternative equation Copyright 1993-2021 Use Caution/Monitor. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Applies only to oral form of both agents. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Anemia; 2015: 763576. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Feraheme does not contain antimicrobial preservatives. The elemental iron product used is Iron sucrose 20 mg/mL. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Applies only to oral form of both agents. Due Date form Ultrasound Report. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Applies only to oral form of both agents. Human studies not conducted. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Ferrlecit may also be administered undiluted as a slow intravenous injection (at a rate of up to 12.5 mg/min) per dialysis session. Oral and parenteral products - see background option for oral products. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Applies only to oral form of both agents. Minor/Significance Unknown. Applies only to oral form of both agents. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Applies only to oral form of both agents. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. elemental iron (mg/ml) in the product being used: Where C= Do not administer Venofer to patients with iron overload. Intravenous iron sucrose for children with iron deficiency failing to Accessed: 4/12/2011. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Venofer may reduce the absorption of concomitantly administered oral iron preparations. Minor/Significance Unknown. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. Applies only to oral form of both agents. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Nutr Clin Pract. Iron Sucrose (Ferogen): Indications, Dosage, Administration - Medcrine Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Use Caution/Monitor. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Applies only to oral form of both agents. Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. 1) Ganzoni AM. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] -Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL) Final calculations: -Hgb iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) -Volume of product required (mL) = [weight (kg)x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Applies only to oral form of both agents. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. *Administer early during the dialysis session. This calculator will help pinpoint potential causes of anemia based on Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. This site complies with the HONcode standard for trust- worthy health information: verify here. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. PDF Highlights of Prescribing Information Contraindications- Venofer There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. This information is not individual medical advice and does not substitute for the advice of your health care professional. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. If you log out, you will be required to enter your username and password the next time you visit. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. A: Generally acceptable. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Venofer (iron sucrose) 20 mg iron / ml, solution for injection or Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. however iron sucrose requires multiple small intermittent doses over days to weeks. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. restrictions. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. iron sucrose increases levels of calcium citrate by enhancing GI absorption. Objective. Minor/Significance Unknown. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. . Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. This may be helped by giving the medication more slowly or at a lower dose. Med J Aust; 193(9):525-32. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Avoid or Use Alternate Drug. Interaction only with oral iron administration. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Contact the applicable plan Ferritin and transferrin are also recommended monitoring . In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Last updated on Jun 1, 2022. Schweiz Med Wochenschr. Reactions have occurred following the first dose or subsequent doses of Venofer. Applies only to oral form of both agents. . HOW TO USE: This medication is given by injection into a vein as directed by your doctor. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Applies only to oral form of both agents. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Avoid or Use Alternate Drug. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. May increase risk of hypotension. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Iron deficiency anemia is the type of anemia caused by iron depletion. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Avoid or Use Alternate Drug. LBW = Lean body weight in kg. Administer on 5 different occasions over a 14 day period. Use alternatives if available. Use Caution/Monitor. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Venofer (iron sucrose) dose, indications, adverse effects - PDR sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. Minor/Significance Unknown. trientine, iron sucrose. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. Interaction only with oral iron administration. J Lab Clin Med; 111(5):566-70. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). Learn how to store and discard medical supplies safely. Formula for calculating the required dose of iron sucrose 1. dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Read our. Avoid or Use Alternate Drug. Minor/Significance Unknown. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Iron Deficit - Multi-Calc - GlobalRPH - Medical Calculators, Clinicians Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. View the formulary and any restrictions for each plan. Minor/Significance Unknown. If you have private insurance, Venofer or Monoferric may be on the list of covered medications. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) Use Caution/Monitor. official version of the modified score here. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. For additional Safety Information, please see Full Prescribing Information. Applies only to oral form of both agents. gymnema decreases levels of iron sucrose by inhibition of GI absorption. Avoid or Use Alternate Drug. STORAGE: Consult the product instructions and your pharmacist for storage details. This topic . Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Use Caution/Monitor. Separate dosing of tetracyclines from these products. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. Applies only to oral form of both agents. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Either increases effects of the other by pharmacodynamic synergism. commonly, these are generic drugs. Modify Therapy/Monitor Closely. IDA diagnosis is based on full blood examination and on the serum ferritin level. 1988 May;111(5):566-70. Use Caution/Monitor. By using this form you agree with the storage and handling of your data by this website. The recipient will receive more details and instructions to access this offer. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] Burns DL, Mascioli EA, Bistrian BR. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 Your dosage and length of treatment are based on your medical condition, age, and response to treatment. David McAuley, Pharm.D. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. 2012;2(4):288-335. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. Applies only to oral form of both agents. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Use Caution/Monitor. Your list will be saved and can be edited at any time. 1970;100(7):301303. Applies only to oral form of both agents. Venofer must only be administered intravenously either by slow injection or by infusion. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). Use Caution/Monitor. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . Applies only to oral form of both agents. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. Properly discard this product when it is expired or no longer needed. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Crown Rump Length and Nuchal Translucency. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . provider for the most current information. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. . The dosage of Venofer is expressed in mg of elemental iron. 1996 Aug;11(4):139-46. Official Journal of the International Society of Nephrology. Applies only to oral form of both agents. VenAccess is a trademark of Vifor (International) Inc. Switzerland. All Rights Reserved. Avoid or Use Alternate Drug. Venofer is given as an infusion into a vein. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed?
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